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The control and ASA30 groups were exposed to room air during the exposure process and received a daily oral gavage of tris-base and ASA (30 mg/kg), respectively, for eleven executive days

Variants were analyzed according to best practice guidelines for the evaluation of pathogenicity and the reporting of sequence variants in clinical molecular genetics (2020, Association for Clinical Genomic Science, Confirmation of clinically significant sequence variants by Sanger sequencing was performed as necessary