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Introduction Primary Sjgren syndrome (pSS) is a systemic autoimmune disease characterised by dryness in the mouth and eyes, chronic pain and fatigue and several other extraglandular manifestations ( 2 ) indicates a positive result ( + T cells with T helper 1 (Th1) and Th2 phenotypes are present, Th17 and follicular helper T (Tfh) cells predominate and may provide a stimulus for B lymphocytes

Ultimately, these data should inform biomarker-enriched, early-phase clinical trials that co-stratify patients by pathway activity and genomic alterations, thereby accelerating the development of precision therapies for women with EAOC

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Children and adolescents: no human pediatric data