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A similarly acting drug developed by the pharmaceutical company Pfizer, named CE, confirmed this finding by testing rats at an even longer delay than previously investigated with Rimonabant, and also found enhanced spatial memory consolidation

Furthermore, treatment of LNCaP prostate cancer cells with this trace mineral was found to cause an induction of GSTP1, APC and CSR1 promoter demethylation (through a decrease in the protein levels of DNMT1), in addition to a reduction in HDAC activity, leading to increased acetylation together with decreased methylation levels of lysine 9 on histone H3, which promoted gene expression ( Reference Xiang, Zhao and Song 64 )

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