It promotes cell migration to injured areas, reduces inflammation on a system-wide basis, and enhances tissue repair across multiple sites simultaneously
This in turn doubles the capacity of the available growth factors to promote signaling cascades necessary for cell development and regeneration
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Cultured human umbilical vein ECs (HUVECs), in particular, express typical molecular markers, including CD31, von Willebrand factor (VWF), CD34, intercellular adhesion molecule-1 (ICAM-1), E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and angiotensin I converting enzyme (ACE) [15, 16] (Table 1)