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3 Neurogenic inflammation in migraine Neurogenic inflammation is defined as an acute sterile inflammation triggered by the release of neuropeptides from peripheral nociceptive fibers, leading to plasma protein extravasation and vasodilation (10)

It inhibits NF-kB and pro-inflammatory cytokines like TNF- and IL-6making it ideal for chronic inflammatory gut conditions

The CstB loop is stabilized by several factors, including the H-bonding interaction of R154 to the P200 amide oxygen, the H-bonding interactions of K203 to the sidechains of S234 and S237 (Fig

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