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In addition, melatonin inhibits the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) 75 and limits the production of excessive amounts of prostanoids and leukotrienes and nitric oxide (NO), as well as other mediators of the inflammatory process, such as chemokines and adhesion molecules 73,76 (Fig

A novel splice site mutation in neonatal carnitine palmitoyl transferase II deficiency