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General dysfunction would precede death, and it is loss of vital cuproprotein-based function in still living neurons that we argue is also key to AD

The connection between sleep quality and shoulder pain is bidirectional: shoulder pain disrupts sleep, and poor sleep impairs healing

Cost: Higher than topical approaches but potentially more cost-effective per result due to improved efficacy

Additionally, funding agencies can also consider funding for degradation and toxicity studies that use high dimensional techniques such as siRNA seq, mass cytometry, and special transcriptomics to demonstrate single cell and tissue level toxicity of degradation products