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population, and heart disease, which accounts for one in every three deaths.44 45 Berberine, a golden yellow compound found in several plants, might play a role in preventing or slowing the progression of both heart disease and diabetes, among several other medical conditions

Ensuring adequate availability of all essential amino acids is therefore critical for leucine-mediated stimulation of muscle protein synthesis and optimal metabolic outcomes (5254)

These include the presence of BMLs, fibrosis, microfractures, and abnormal vascularization, which strongly correlate with pain severity and structural disease progression (Seref-Ferlengez et al., 2015)