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While these medications have a relatively low intrinsic risk of causing dangerously low blood sugar when used alone, the risk increases significantly when combined with insulin or sulfonylureas

2B), we tested whether the decrease in GCLC expression is mediated by the regulated Ire1-dependent decay (RIDD) activity of IRE1 through its RNase domain 18

Concomitantly with the development of resistance the up-regulation of a hydrogen-peroxide inducible GST was observed that might contribute to the elimination of cytotoxic reactive metabolites containing an electrophilic moiety (Shibu et al., T