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HIF-1-dependent induction of retinoic acid-receptor-related orphan receptor-t (RORt) combined with targeting FOXP3 for degradation is detrimental to Treg cells and fosters Th17 cell generation (84), identifying hypoxia as a potent risk factor for unrelenting inflammation

CL and DW performed recombinant expression and purification of GST proteins

[9,10,22,25,27,28,53,56] pCons-induced T regs suppress the production of anti-dsDNA autoantibodies, reduce proteinuria, and delay nephritis in murine lupus