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A multidisciplinary approach, involving personalized addiction care and case management, may provide further benefit in managing alcohol dependence.[9] Following DAA-based therapy, one study that included 123 participants found provider-delivered, alcohol-related counseling during HCV treatment was successful in reducing alcohol consumption patterns both during and after treatment in individuals with harmful alcohol use.[64] HCV Treatment in Persons who Use Cannabis There is mixed evidence regarding cannabis use and HCV-related hepatic fibrosis progression.[65,66,67] Two separate longitudinal cohort studies found no association between cannabis use and progression of liver fibrosis among patients coinfected with HCV and HIV.[65,68] In addition, one study found a positive association between cannabis use and good adherence with HCV treatment.[69] Although individuals living with HCV are typically advised to abstain from regular cannabis use, ongoing cannabis use is not considered a contraindication for initiating HCV therapy