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Lactylation, primarily catalyzed by enzymes such as p300/CBP and derived from intracellular lactate, modulates gene expression programs linked to glycolysis, angiogenesis, and immunosuppression [322]

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Therefore, for purposes of this impact analysis, we are proposing to apply an adjustment of 0.980959 to ensure that the effects of the reclassifications under sections 1886(d)(8)(B) and (C) and 1886(d)(10) of the Act are budget neutral (section II.A

GSSG is therefore likely to be more beneficial than GSH, especially for topical use