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Jan, Stanford University, United States Reviewed by Eric Bielefeld, The Ohio State University, United States

Symptoms as Toxicity Develops As the combined depressant load increases, the following symptoms become more likely and more severe than with GHB alone: Deepening sedation that becomes impossible to fight Vomiting while consciousness is reduced, creating a serious aspiration risk Significant drops in blood pressure Slowed or shallow breathing Falling oxygen levels Loss of the gag reflex that normally protects the airway Abrupt loss of consciousness or coma The vomiting and sedation combination is especially dangerous

CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing