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This is a significant gap that complicates dosing optimization and raises questions about long-term effects that cannot be fully answered yet

Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) (Kalsi et al., 2011