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Additionally, prolonged neglect of the injury can lead to further damage, potentially requiring more complex treatment in the future
Laske C, Stransky E, Eschweiler GW, Klein R, Wittorf A, Leyhe T, et al
Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions
The copper ion is essential to its biological activity, serving as a cofactor for enzymes involved in tissue repair
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