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How dual GIP and GLP-1 activation works at low doses Understanding why microdosing tirzepatide is different from microdosing semaglutide requires understanding the dual-agonist mechanism and how it behaves at sub-therapeutic concentrations

Conducted at the Fondazione IRCCS Ca Granda Policlinico of Milan, this prospective case series included 52 infertile women who followed a structured VLCKD using medical meal replacements and controlled supplementation for 3 months, followed by a gradual transition to a Mediterranean-style diet