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This reaction occurs at a rate 10- to 30-fold higher than the hydrolysis of TAG, which is the initiating and rate-limiting step in lipolysis (40)

GRAS simply means the FDA agrees that the substance, at intended use levels as a food additive or supplement, is safe based on common use history or expert opinion and does not pose acute toxicity concerns

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Treatment with EGRIFTA resulted in an increase from baseline in mean lean body mass of 1.3 kg in Study 1 and of 1.2 kg in Study 2, respectively (compared with a decrease of 0.2 kg in Study 1 and of 0.03 kg in Study 2, respectively, in patients receiving placebo)