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We also factored in annual operating costs (filter replacements and energy use), which vary widely between models

The protocol and systematic reviews were externally reviewed by expert peer reviewers and organizational interest holders, with 29 reviewers providing input on the draft version of this guideline

No one has made a cigarette that is significantly decreased in all of these [chemicals] and is still something people would want to smoke, even though the industry has worked on this for around 50 years, says Hecht