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Surprisingly, no difference between sg CBS and sgRNA controls was detected for intracellular cysteine or GSH levels (Supplementary Fig

This was clearly demonstrated by a study in which primary cortical neurons treated with subtoxic levels of the GSH-depleting agent, buthionine sulfoximine (BSO), underwent apoptosis in the presence of trace amounts of extracellular copper [17]

Acknowledgements The authors would like to extend their deepest gratitude to the researchers whose pioneering work laid the foundation for this review

Speaking with a healthcare provider before using any form of treatment, including glutathione injections, is important