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CPE could clearly be seen after 12 h (compared with negative controls)

STAT3 signaling controls cellular senescence and immunosenescence There is clear evidence that insulin/IGF-1 exposure can induce/augment the cellular senescence of different non-immune cells in several experimental conditions [144,145,146,147]

We used a previously reported small-molecule peptide that competently inhibits -syn hyperphosphorylation at ser129 [13] and administered it to mice via the tail vein (Fig

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