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[456] Alliance One,Company Overview, and Frequently Asked Questions, (both accessed February 5, 2014)

Tobacco is a high cost, high risk crop, very vulnerable to the vagaries of the weather, easily damaged by wind or frost or ruined in a few minutes by a summer hailstorm

1700 Massachusetts Puritan Samuel Sewall publishes The Selling of Joseph , probably the first antislavery tract in the colonies

These include how often and how much tobacco they consume, biochemical markers (such as levels of cotinine, a by-product of nicotine metabolism) (covered in 12.5.6 Biomarkers of tobacco smoke and damage), and self-reported smoking behaviour measured in questionnaires