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Opioids inhibit NOS (Kampa et al., 2001), and this inhibition may need to be well-correlated with other effects of opioids (perhaps at NMDA coincidence detectors?) in order for the plasticity required for tolerance to occur
Essential for serious NNMT research
B12 injections are most clearly indicated when: A person has confirmed B12 deficiency that requires rapid replacement Theres a known or likely absorption issue Theres a need for ongoing maintenance due to non-dietary causes (for example, autoimmune gastritis) Typical treatment schedules (UK guidance) Treatment schedules can vary depending on symptoms, severity, and cause
Cellular methylation and NAD pool dynamics the only well-characterized chemical probe that simultaneously raises tissue NAD and SAM, enabling clean studies of the methyl-donor / NAD-salvage interface [1,2]
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