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Among others, actions of IGF-I on cardiac stem cells include antioxidant effects, upregulation of telomerase activity, a delay in replicative senescence[288], and migration and homing of cardiac stem cells facilitating neovascularization in damaged hearts[287]

10.1007/s12192-017-0847-0 63 IchimuraY.WaguriS.SouY

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HSPA5/GRP78/BiP The accumulation of unfolded or misfolded proteins in the ER activates a signaling pathway known as the unfolded protein response (UPRER), which is regulated by three main sensors: protein kinase RNA-like ER kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6)