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For example, reduced EAAT2 activity leads to elevated extracellular glutamate concentrations [309, 310], which trigger excessive calcium influx into both neurons and astrocytes

Such accumulation also promotes cell wall metabolism and cross-linking through oxidative processes

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Each individual component has been studied in preclinical models: BPC-157 (molecular weight: 1419.556 g/mol) is a synthetic fragment derived from a gastric protein, frequently examined in rodent studies on gastrointestinal integrity, vascular changes, and soft-tissue injury