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MT-1 (afamelanotide): Selective for MC1R (melanin production receptor) 13-residue linear peptide FDA-approved for EPP Side effects: typically headache, fatigue, nausea generally mild More expensive per dose, more conservative tanning MT-2: Activates MC1R, MC3R, MC4R, MC5R broader receptor profile 7-residue cyclic peptide (smaller) Not FDA-approved Side effects: nausea, flushing, libido effects (MC4R activation), potential melanoma concerns with new moles Cheaper per dose, faster/darker tanning For tanning users prioritizing safety profile and tolerability, MT-1 is the more documented option despite higher per-mg cost

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(2021) Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial