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Elevated IGF-1 levels raise concerns about potential proliferative effects on existing malignancies, making growth hormone therapy problematic for individuals with cancer history or elevated cancer risk

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Across biochemical assays, cell culture models, and preclinical animal studies, mechanistic investigations have focused on how BPC-157 interacts with nitric oxide signaling, angiogenic regulation, cytoskeletal remodeling, and epithelial or connective tissue repair processes

The REW variant also showed enhanced C1q binding compared to other half-life extended IgG1 Fc-engineered variants (SI Text 5, Fig