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[1] [4] But the depth of the safety record, and the labeling attached to it, differs sharply

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In rodent models, reported effects in tendon, ligament, muscle and gastrointestinal tissue have been attributed to modulation of the VEGFR2 / nitric oxide pathway, upregulation of growth-hormone receptor expression in fibroblasts, and effects on FAKpaxillin signalling that influence cell migration