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A recent analysis using Mendelian randomization showed that genetically predicted homocysteine levels increased the odds of NAFLD.[ref] Related article: NAFLD genes Cardiovascular disease: To answer the question of whether a modestly elevated homocysteine level is causally associated with an increased risk of cardiovascular disease, researchers again used huge genetic data sets and Mendelian randomization to determine causality

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L-Arginine research signals: A systematic review and meta-analysis of randomized clinical trials on L-Arginine supplementation and blood pressure found generally positive signals in populations with elevated blood pressure, though the evidence shows significant heterogeneity across studies

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