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Given the clinical significance of even small effect sizes associated with quitting [10], optimizing the use and efficacy of the nicotine patch is a pragmatic and feasible approach to the continuing problem of tobacco use disorder in the current, hard-to-treat population of smokers

[59] John Shannon, "The Prospects for Federal Legislation against Cigarette Smuggling," Proceedings of the 51 st Annual Meeting of the National Tobacco Tax Association State AND Federal Responsibility , (Chicago: Federation of Tax Administrators, 1977), 26