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Without adequate glutathione stores, Phase 1 toxic intermediates accumulate in the liver and bloodstream, causing severe systemic inflammation and triggering hypersensitivity reactions commonly seen in patients with complex chronic illnesses

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Acrolein can react and form adducts with DNA, lipids and proteins leading to cellular damage in several human tissues

vinifera cell cultures and shown to be involved in extracellular transport of trans-resveratrols: grapevine cell cultures overexpressing GSTU-2 accumulated trans-resveratrols in the extracellular medium even without any elicitation of plant defenses or pathogen infection (Martnez-Mrquez et al., Vitis flexuosa different GTSs may play diverse roles in pathogen defense, since only one out of five characterized GST genes was induced, while expression of the other GSTs was down-regulated following infection by the necrotrophic fungi B