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Answer: Results can be seen between 2 - 4 weeks of consistent use

Nature Genetics, Volume 10, Issue 1, May 1995, Pages 111-113 Marvin Boris, M.D

Summary: Its More Than Skin Deep Rosacea isnt just a skin issue its a multi-system condition that needs a multi-pronged approach

PE treatment for 48 h was associated with significantly elevated ROS production relative to the levels observed in the control or PQQ treatment groups, while PQQ effectively reversed PE-induced ROS production (Figure 4A)