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They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology

Further analyses considered whether age and body mass index (BMI) might modify these effects

Frustratingly, present medication only target concomitant symptoms rather than the core symptoms of autism, and the development of key molecular targets for signal transduction pathways is still in the basic research

doi: 10.3390/MA9070599 156 SceglovsA.WychowaniecJ