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Indeed, it is known that Nrf2 is a master factor for the regulation of antioxidant response elements (ARE) in several antioxidant and phase II detoxifying proteins in different cell types, including nerve cells (Kobayashi and Yamamoto, Figure 4 The results obtained in the hippocampus of WT mice were particularly interesting, since transcriptional activation of all Gpx4 isoforms was significantly higher under the Low-DHA dietary condition compared to the High-DHA diet

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Within the framework of the oral respiratory axis, metabolites produced by oral microorganisms may also act as signaling molecules

To better understand these differential cellular effects of TQ, more in vitro, in vivo , and in silico studies should be conducted at both proteomic and genomic level