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Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice

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NAPRT modulators Apart from the targets discussed above, one of the less explored yet crucial enzymes in NAD + biosynthesis is NAPRT, the rate-limiting enzyme of the PreissHandler pathway