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In the loading dose group, daily intranasal cobalamin administration led to a rapid rise in total serum vitamin B12 levels, increasing from a median of 230 to 1090 pmol/L within two weeks

Ito S, Tamura T, Nishikawa M

For example, physical hindrances can include fatigue, discomfort, and underlying medical conditions

A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria