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Despite major technological advances, the pharmaceutical industry has experienced a consistent decline in R&D efficiency over the past six decades, with the number of new drugs approved per billion US dollars spent halving approximately every nine years, a trend referred to as Erooms Law (Moores Law backwards) 1

Increased AMP levels activate Adenosine Monophosphate-Activated Protein Kinase (AMPK), which contributes to lowering of glucose production by at least 2 pathways: i) increased AMPK phosphorylates CBP & CRTC2 transcription factors, which inhibits genes involved in the production of glucose (gluconeogenic genes)

Spinach is abundant in Glutathione- containing antioxidants

Due to the dysregulation of GLS in a variety of cancers, GLS inhibition has attracted attention