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Subsequently, reduction of the disulfide bonds by a disulfide isomerase may separate the two molecules and lead to shedding of the alpha subunit, which can be augmented by TSH stimulation of thyroid cells (237)

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Evidence that TSH receptor A-subunit multimers, not monomers, drive antibody affinity maturation in Graves disease

Insomnia, defined by persistent difficulty in initiating or maintaining sleep, affects millions globally, leading to impaired cognitive function, emotional distress, weakened immunity, and increased risk of metabolic and cardiovascular disease