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Xc system is crucial in regulating ferroptosis and SLC7A11 facilitates the exchange of extracellular cystine and intracellular glutamate across the plasma membrane, as well as the reduction of cystine to cysteine within cells, which is essential for GSH production [75]

(2019), identifies FSP1 as the second mainstay of ferroptosis protection, beyond GPX4

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