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These reactions typically resolve with continued use as the skin acclimates, or with dose reduction

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway in experimental traumatic brain injury

Use sunscreen in the morning to prevent dullness and pigmentation

This supports a direct interaction, although their underlying mechanisms are still in the early stages of investigation and further studies with larger sample sizes or validation are required (Wang Q