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Reasoning that the enzymes encoded by these genes could be responsible for the utilization of l-carnitine and its conversion to BB (Figure 7C), we used comparative genomics tools to identify 3 other organisms that contain the caiTABCDE gene operon (Supplemental Figure 5), and assessed their ability to consume l-carnitine and produce BB (Figure 8)

H.et al (2005)

1 2 3 The New England Journal of Medicine

At the molecular level, the balance of anabolic and catabolic (protein degrading) processes is coordinated primarily by the phosphoinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)/Forkhead boxO3a (FOXO3a) pathway among others (Glass, 2005)