Therefore, enhanced glutaminolysis might eventually contribute to the initiation and progression of cancer by stimulating cell growth via the mTORC1 pathway and enhancing aerobic glycolysis while disrupting the proper elimination of misfolded proteins, damaged DNA and organelles through the inhibition of autophagy and the DNA damage response 166
To investigate whether ROS was host or pathogen generated, a separate experiment was conducted in which cells were infected with 1 MOI zoospores (T#5), and either: 1) supplemented with 2.5 mM cysteine on day 3 for 8 hr, 2) incubated at 27C for 8 hr, 3) supplemented with 1.5 mM cysteine and incubated at 30C for 6 hr
KPV A tripeptide fragment derived from alphaMSH, often studied for its role in immunerelated signaling and cellular regulatory pathways
The reaction mechanism for roGFP2(S 2 ) as a model non-glutathione disulfide substrate resembles the first part of the GSH-dependent reduction of the sulfenic acid of human peroxiredoxin 6 that is catalyzed by glutathione transferase P1-1 (which shares several structural features with glutaredoxins) 7,80,81,82
