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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

10.1152/physrev.00026.2013 Summary Keywords heart failure, mitochondrial dysfunction, fatty acid oxidation, energy metabolism, traditional Chinese medicine Citation Wang M, Zhu Z, He X, Dai S, Liu R and Liu J (2025) The crosstalk between mitochondrial dysfunction and fatty acid metabolism in heart failure: mechanisms and therapeutic strategies

doi: 10.1002/mnfr.201300724 106 HolderGMPlummerJLRyanAJ