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Ferroptotic cancer cells also release danger-associated lipids and iron intermediates that recruit and activate macrophages, creating positive or negative regulatory loops ( 5 Iron homeostasis and immune regulation in the tumor microenvironment 5.1 Impact of macrophage polarization states on iron metabolism During early tumorigenesis, M1-type tumor-associated macrophages (TAMs) facilitate cellular iron uptake via transferrin receptor 1 (TfR1/CD71), while ferritin (FT) restricts iron efflux, resulting in iron sequestration

A positive association between aconitase activity and GSH/GSSG was found in both cerebellum ( P =0.01) and BA22 ( P =0.03) in our combined case and control cohort (correlation coefficients=0.46 and 0.45, respectively)