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Robinson, D.S., Hamid, Q., Bentley, A., Ying, S., Kay, A.B., Durham, S.R., Activation of CD4+ T cells, increased Th2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma, J

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Physiol Rev 75(3):519560 Krishnan L et al (2003) Effects of angiogenesis on the material properties of the extracellular matrix: correlation with gene expression

however, some individuals may experience mild skin sensitivity depending on: Formulation concentration Skin type Frequency of cosmetic application Concurrent cosmetic ingredients Possible Cosmetic Reactions Mild redness Temporary tingling sensations Skin irritation Dryness Increased skin sensitivity Temporary blue discoloration when higher concentrations are utilized Higher concentrations are not always preferred and may increase the likelihood of cosmetic skin irritation, particularly in sensitive-skin formulations