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Castelli et al., 2005)

In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia ( 3.6 Chronic low-grade inflammation Chronic low-grade inflammation have been identified as a central component in the pathogenesis of PCOS, rather than mere accompanying phenomena

Effect of intermittent systemic administration of recombinant parathyroid hormone (1-34) on mandibular fracture healing in rats

However, our study did not directly assess mitochondrial function or ROS levels, and thus, this mechanism remains speculative