One of the main pathomechanisms of AD is oxidative stress, which is closely related to other neurodegenerative events such as impaired calcium homeostasis, metal dysregulation, mitochondrial dysfunction, protein misfolding, inflammation, and impaired autophagy (Nunomura and Perry 2020)
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He J, Zhao C, Zhong S, et al
In tolerance assays forty-two hours after the conditioning regimen, shorter preconvulsive latencies than that in healthy mice following an isoniazid treatment (800 mg/kg i.p.) were observed if diazepam (5.0 mg/kg i.p.) was given again to mice previously conditioned with diazepam alone