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At the 12-month follow-up : 87.5% of patients reported significant relief defined as 50% reduction in baseline pain scores Mean VAS pain score dropped from 7.2 at baseline to 2.8 at 12 months KOOS (Knee Injury and Osteoarthritis Outcome Score) improved across all subscales: pain, symptoms, activities of daily living, sport/recreation, and quality of life No serious adverse events were reported across the treatment period The durability of the response at 12 months is particularly notable

Minoxidil provides relatively quick initial results because it leverages existing follicular machinery, but its effects remain localized to the application site and require continuous use

We also discuss enterovirus infection, particularly by coxsackievirus B (CVB), and its potential role as a critical environmental trigger

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