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The study, published July 30 in Proceedings of the National Academy of Sciences (PNAS) , also points to a breakthrough new class of anti-depressant that is faster-acting and free of side effects than the current treatments that have been in use for the past 30 years

Methods Drug compounds JQ1 (BLDpharm), valproic acid (Sigma-Aldrich) and Tacedinaline (Sigma-Aldrich) were obtained commercially and used without further purification

Peroxynitrite Although the idea that oxidant stress is critical for APAP-induced cell death was largely accepted by the late 1990s, the mechanisms of ROS-induced cell death remained unclear

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