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Compounds that demonstrate clear efficacy in rat tendon healing studies have repeatedly failed to reproduce those effects in human clinical trials this is a documented pattern across pharmaceutical development, not a theoretical concern

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Beyond prodrugs, advances in precision phototherapy emphasize decoding complex tissue microenvironments to spatially and temporally control light-based therapies

Acknowledgments The authors acknowledge the funding of the National Natural Science Foundation of China [No.82173989] and the support from the National Administration of Traditional Chinese Medicine [No.zyyzdxk-2023272]