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Factors that can further reduce glutathione levels include: Chronic stress Poor diet Environmental toxins Excessive alcohol consumption Certain medications Lack of sleep This decline in glutathione levels can contribute to various skin issues, including premature aging, dullness, and increased sensitivity to environmental damage

In mice exposed to Gulf War agents, brain tissue showed evidence of mitochondria disturbances, with astroglia and microglia activation in the hippocampus with significant reductions in Cardiolipin (Abdullah et al., 2016), a strong indicator of decreased activity of the electron transport chain (Shen et al., 2015)